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LINE掲示板/ 至急!! 英語の得意な方、お願いします!! 載せている英文の和訳をしてく

至急!! 英語の得意な方、お願いします!! 載せている英文の和訳をしてください。

至急!! 英語の得意な方、お願いします!! 載せている英文の和訳をしてください。
It has been shown that HCC surveillance of subjects at risk can facilitate tumor detection at an early stage, which in turn may improve survival. Ultrasound (US) has been recommended for HCC surveillance, but the efficacy of this approach is highly operator-dependent. Other imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) may be effective , but are costly and unsuitable as a first-line examination. Given this background, there is a need for sensitive serum markers for early detection of HCC. Alpha-fetoprotein (AFP) has been most widely used for this purpose, but many small HCCs do not secrete a diagnostic level of AFP. A recent study indicated that AFP lacks adequate sensitivity and specificity for effective early diagnosis of HCC. Measurement of the lectin lens culinaris agglutin-bound fraction of AFP (AFP-L3) can improve the specificity. Protein induced by vitamin K absence or antagonist II (PIVKA-II;also referred to as des-gamma-carboxy prothrombin (DCP)) is a tumor marker complementary to AFP, but elevated PIVKA-II levels are found in only 28–47.6% of HCCs smaller than 3 cm. Markers such as glypican-3 have been proposed to be complementary to AFP, but this marker has yet to be widely used, as reviewed elsewhere. Thus, currentlyavailable tumor markers for HCC are not satisfactory in terms of sensitivity and specificity, indicating the need for development of new HCC serum biomarkers. Recent technological advances have made proteomics useful for discovery of markers in various fields of medicine, including the discovery and identification of biomarkers for HCC. Autoantibodies against autologous tumor-associated antigens are also promising targets as biomarkers for early cancer detection . We previously conducted proteome analyses to compare protein expression between surgically resected HCC tissues and adjacent nontumor tissues using agarose two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) .